Background Percutaneous coronary intervention (PCI) is increasingly used to treat
unprotected left main coronary artery stenosis, although coronary-artery bypass grafting
(CABG) has been considered to be the treatment of choice. Methods We randomly assigned
patients with unprotected left main coronary artery stenosis to undergo CABG (300 patients)
or PCI with sirolimus-eluting stents (300 patients). Using a wide margin for noninferiority, we
compared the groups with respect to the primary composite end point of major adverse …

Background: In a previous randomized trial, we found that percutaneous coronary
intervention (PCI) was not inferior to coronary artery bypass grafting (CABG) for the
treatment of unprotected left main coronary artery stenosis at 1 year. Objectives: This study
sought to determine the 5-year outcomes of PCI compared with CABG for the treatment of
unprotected left main coronary artery stenosis. Methods: We randomly assigned 600
patients with unprotected left main coronary artery stenosis to undergo PCI with a sirolimus …