[HTML][HTML] Rapid adipose deposition with mood disorders
JG Fiedorowicz, LE Andersen, JE Persons… - Annals of clinical …, 2015 - ncbi.nlm.nih.gov
JG Fiedorowicz, LE Andersen, JE Persons, C Calarge
Annals of clinical psychiatry: official journal of the American …, 2015•ncbi.nlm.nih.govBACKGROUND Persons with bipolar disorders represent a high risk group for obesity, but
little is known about the time course by which weight gain occurs in bipolar disorder.
METHODS We prospectively studied changes in fat distribution using dual-energy X-ray
absorptiometry in relationship to medication exposure and mood symptom burden in thirty-
six participants with bipolar disorders. We assessed the relationship between prior
medication exposure and course of illness with adiposity measures at baseline in the full …
little is known about the time course by which weight gain occurs in bipolar disorder.
METHODS We prospectively studied changes in fat distribution using dual-energy X-ray
absorptiometry in relationship to medication exposure and mood symptom burden in thirty-
six participants with bipolar disorders. We assessed the relationship between prior
medication exposure and course of illness with adiposity measures at baseline in the full …
Abstract
BACKGROUND
Persons with bipolar disorders represent a high risk group for obesity, but little is known about the time course by which weight gain occurs in bipolar disorder.
METHODS
We prospectively studied changes in fat distribution using dual-energy X-ray absorptiometry in relationship to medication exposure and mood symptom burden in thirty-six participants with bipolar disorders. We assessed the relationship between prior medication exposure and course of illness with adiposity measures at baseline in the full sample and at 6-month follow-up in 22 individuals.
RESULTS
At baseline, greater adiposity was associated with only advanced age and female sex, not retrospectively assessed symptom course or medication exposure (past two years). Over six months of prospective follow-up, participants developed greater adiposity (fat mass index+ 0.82 kg/m 2, p= 0.007; visceral fat area+ 8.6 cm 2, p= 0.02; total percent fat+ 1.6%, p= 0.02). Manic symptomatology, not antipsychotic exposure, was related to the increased adiposity.
CONCLUSIONS
Acute exacerbations of mood disorders appear to represent high risk periods for adipose deposition. Obesity prevention efforts may be necessary during acute exacerbations.
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