[HTML][HTML] Ras downstream effector GGCT alleviates oncogenic stress
How cells adapt to oncogenic transformation-associated cellular stress and become fully
transformed is still unknown. Here we identified a novel GGCT-regulated glutathione (GSH)-
reactive oxygen species (ROS) metabolic pathway in oncogenic stress alleviation. We
identified GGCT as a target of oncogenic Ras and that it is required for oncogenic Ras-
induced primary mouse cell proliferation and transformation and in vivo lung cancer
formation in the LSL-Kras G12D mouse model. However, GGCT deficiency is compatible …
transformed is still unknown. Here we identified a novel GGCT-regulated glutathione (GSH)-
reactive oxygen species (ROS) metabolic pathway in oncogenic stress alleviation. We
identified GGCT as a target of oncogenic Ras and that it is required for oncogenic Ras-
induced primary mouse cell proliferation and transformation and in vivo lung cancer
formation in the LSL-Kras G12D mouse model. However, GGCT deficiency is compatible …
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