Rational chemical design of molecular glue degraders
ES Toriki, JW Papatzimas, K Nishikawa… - ACS central …, 2023 - ACS Publications
Targeted protein degradation with molecular glue degraders has arisen as a powerful
therapeutic modality for eliminating classically undruggable disease-causing proteins
through proteasome-mediated degradation. However, we currently lack rational chemical
design principles for converting protein-targeting ligands into molecular glue degraders. To
overcome this challenge, we sought to identify a transposable chemical handle that would
convert protein-targeting ligands into molecular degraders of their corresponding targets …
therapeutic modality for eliminating classically undruggable disease-causing proteins
through proteasome-mediated degradation. However, we currently lack rational chemical
design principles for converting protein-targeting ligands into molecular glue degraders. To
overcome this challenge, we sought to identify a transposable chemical handle that would
convert protein-targeting ligands into molecular degraders of their corresponding targets …
Rational Chemical Design of Molecular Glue Degraders
J McKenna, D Dovala, A Frank, M Hesse… - ACS Central …, 2023 - oak.novartis.com
Targeted protein degradation with molecular glue degraders has arisen as a powerful
therapeutic modality for eliminating classically undruggable disease-causing proteins
through proteasome-mediated degradation. However, we currently lack rational chemical
design principles for converting protein-targeting ligands into molecular glue degraders. To
overcome this challenge, we sought to identify a transposable chemical handle that would
convert protein-targeting ligands into molecular degraders of their corresponding targets …
therapeutic modality for eliminating classically undruggable disease-causing proteins
through proteasome-mediated degradation. However, we currently lack rational chemical
design principles for converting protein-targeting ligands into molecular glue degraders. To
overcome this challenge, we sought to identify a transposable chemical handle that would
convert protein-targeting ligands into molecular degraders of their corresponding targets …
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