Coxiella burnetii is an obligate intracellular Gram-negative bacterium and the causative
agent of a worldwide zoonosis known as Q fever. The pathogen invades monocytes and
macrophages, replicating within acidic phagolysosomes and evading host defenses through
different immune evasion strategies that are mainly associated with the structure of its
lipopolysaccharide. The main transmission routes are aerosols and ingestion of fomites from
infected animals. The innate immune system provides the first host defense against the …