… and podocyte repair is an important therapeutic target. In Fabry disease, podocyte injury
is … This study identifies in the human podocyte three endocytic receptors, mannose 6-phosphate/…

… Fabry disease, podocyte injury is caused by the intracellular accumulation of
globotriaosylceramide. This study identifies in the human podocyte three endocytic … in the …

… Hence, the effectiveness of treatment with ERT in Fabry disease needs further clarification
… in the receptor-mediated uptake of recombinant α-Gal A in human podocytes and HEK293 …

… Fabry disease and control immortalized human podocytes using a high-throughput
phosphorylation microarray. Fabry disease podocytes … the lysosomal hydrolase α -galactosidase A …

… of α -Galactosidase A into cells relevant to Fabry disease, in … α -Galactosidase A uptake was
examined in fibroblasts, four … by storage in Fabry disease (cardiomyocytes, renal podocytes, …

… in Fabry disease, a glycosphingolipidosis caused by deficient activity of α-galactosidase A
(α-… Cardiomyocytes, podocytes, and peripheral neurons represent the major hard-to-reach cell …

… Fabry disease is caused by deficient activity of α-galactosidase A and subsequent …
moss-aGal into FMEC2 was via receptor-mediated endocytosis or non-specific pinocytosis, …

… Deficiency of lysosomal α-galactosidase A (α-Gal A) in Fabry disease results in cellular … is
taken up by podocytes and reabsorbed by receptor-mediated endocytosis in proximal tubule …

… in α-galactosidase A-deficient podocytes may be the result of deficient mTOR kinase activity.
This finding links the lysosomal enzymatic defect in Fabry’s disease … of Fabry's disease we …

… Fabry disease (FD) is a lysosomal storage disorder (LSD) characterized by the deficiency of
α-galactosidase A (… Of note, in a human podocyte cell line, three endocytic receptors, IGF2R/…