Reduction of Na/K-ATPase potentiates marinobufagenin-induced cardiac dysfunction and myocyte apoptosis
C Liu, Y Bai, Y Chen, Y Wang, Y Sottejeau, L Liu… - Journal of Biological …, 2012 - ASBMB
Decreases in cardiac Na/K-ATPase have been documented in patients with heart failure.
Reduction of Na/K-ATPase α1 also contributes to the deficiency in cardiac contractility in
animal models. Our previous studies demonstrate that reduction of cellular Na/K-ATPase
causes cell growth inhibition and cell death in renal proximal tubule cells. To test whether
reduction of Na/K-ATPase in combination with increased cardiotonic steroids causes cardiac
myocyte death and cardiac dysfunction, we examined heart function in Na/K-ATPase α1 …
Reduction of Na/K-ATPase α1 also contributes to the deficiency in cardiac contractility in
animal models. Our previous studies demonstrate that reduction of cellular Na/K-ATPase
causes cell growth inhibition and cell death in renal proximal tubule cells. To test whether
reduction of Na/K-ATPase in combination with increased cardiotonic steroids causes cardiac
myocyte death and cardiac dysfunction, we examined heart function in Na/K-ATPase α1 …