Objective To assess the efficacy and safety of Reduning injection for fever, rash, and ulcers
in children with mild hand, foot, and mouth disease (HFMD). Methods A stratified-block
randomized, double-blind, parallel-controlled, and multicenter clinical trial was conducted
with 360 patients in five hospitals across China: Quanzhou Children's Hospital,
Shijiazhuang No. 5 Hospital, Shanghai Public Health Centre, Hunan Provincial Children's
Hospital, and Kaifeng Children's Hospital. Patients were randomized into three groups with …

Reduning injection is a new herb-based drug composed of three antiviral herbs: Qing Hao
(Artemisiae annuae Herba), Jin Yin Hua (Lonicerae Flos) and Zhi Zi (Gardeniae Fructus). In
this randomised, double-blind, controlled, multi-centre clinical trial, 360 children with hand,
foot, and mouth disease (HFMD, involving symptoms of fever, rashes and ulcers) were
allocated to three groups: Western medicine, Reduning injection, and combined Reduning
injection and Western medicine. The results showed that Reduning injection combined with …