Region-and peptide-specific regulation of the neurotrophins by estrogen
MK Jezierski, F Sohrabji - Molecular Brain Research, 2000 - Elsevier
We have previously shown that estrogen increases the expression of brain-derived
neurotrophic factor (BDNF) mRNA in the olfactory bulb and cingulate cortex. Here we report
that estrogen regulation of BDNF protein and the structurally related peptides nerve growth
factor (NGF) and neurotrophin (NT)-4 is region-and peptide-specific. The olfactory bulb and
cingulate cortex are both estrogen-sensitive targets and each receives a separate projection
from neurons in the horizontal limb of the diagonal band of Broca (hlDBB). Furthermore …
neurotrophic factor (BDNF) mRNA in the olfactory bulb and cingulate cortex. Here we report
that estrogen regulation of BDNF protein and the structurally related peptides nerve growth
factor (NGF) and neurotrophin (NT)-4 is region-and peptide-specific. The olfactory bulb and
cingulate cortex are both estrogen-sensitive targets and each receives a separate projection
from neurons in the horizontal limb of the diagonal band of Broca (hlDBB). Furthermore …
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