[HTML][HTML] Regulatable gene expression systems for gene therapy applications: progress and future challenges
S Goverdhana, M Puntel, W Xiong, JM Zirger, C Barcia… - Molecular Therapy, 2005 - cell.com
… and progesterone analogue-inducible systems. Some of the challenges still remaining in
all regulatable gene expression systems include leaky gene expression in the off state, which …
all regulatable gene expression systems include leaky gene expression in the off state, which …
Regulatable gene expression systems for gene therapy
N Vilaboa, R Voellmy - Current gene therapy, 2006 - ingentaconnect.com
… of hsp gene regulation, not only … gene expression than chemicals. As shown by multiple
studies that assessed heat induction of endogenous hsp genes or of transduced reporter genes …
studies that assessed heat induction of endogenous hsp genes or of transduced reporter genes …
[PDF][PDF] Regulatable gene expression systems for gene therapy applications: progress and future challenges
S Goverdhana, M Puntel, W Xiong, JM Zirger… - … gene therapy, 2006 - researchgate.net
… limited or no therapeutic options. Below, we will review the importance and challenges of
the future implementation of regulatable gene expression systems in gene therapy clinical trials…
the future implementation of regulatable gene expression systems in gene therapy clinical trials…
[HTML][HTML] Regulatable systems: applications in gene therapy and replicating viruses
S Agha-Mohammadi, MT Lotze - The Journal of Clinical …, 2000 - Am Soc Clin Investig
… of therapeutic genes to targeted mammalian cells as well as regulatable gene expression.
Advances in gene therapy have mainly focused on the development of viral …
Advances in gene therapy have mainly focused on the development of viral …
Inducible control of gene expression: prospects for gene therapy
CT Caskey - Current opinion in chemical biology, 1998 - Elsevier
… -regulated gene expression systems are available for controlling target gene transcription
through the use of small-molecule inducing compounds. While the utility of such systems has …
through the use of small-molecule inducing compounds. While the utility of such systems has …
Gene therapy progress and prospects: transcription regulatory systems
C Toniatti, H Bujard, R Cortese, G Ciliberto - Gene therapy, 2004 - nature.com
… To be used in human gene therapy, a pharmacologically regulated system should fulfill …
be exploited to generate a series of gene regulation systems. The generation of an additional …
be exploited to generate a series of gene regulation systems. The generation of an additional …
Pharmacologic transgene control systems for gene therapy
W Weber, M Fussenegger - The Journal of Gene Medicine: A …, 2006 - Wiley Online Library
… for the delivery of regulated transgene expression and the impact of conditional … A panoply
of different inducible mammalian cell-compatible gene regulation systems was developed in …
of different inducible mammalian cell-compatible gene regulation systems was developed in …
Gene regulation systems for gene therapy applications in the central nervous system
… in gene regulation has been at the transcriptional level and as such gene regulation systems
… The tetracycline regulated gene expression system developed by Gossen and Bujard [2] is …
… The tetracycline regulated gene expression system developed by Gossen and Bujard [2] is …
Regulated gene therapy
L Breger, EE Wettergren, L Quintino… - Gene Therapy for …, 2016 - Springer
… Many different regulated gene expression systems … regulation of genes by gene therapy
. Two are active at the transcriptional level and target either transgenic or endogenous genes. …
. Two are active at the transcriptional level and target either transgenic or endogenous genes. …
Gene transfer: the challenge of regulated gene expression
… regulatable systems for controlled gene expression and strategies and potential problems for
optimizing transgene expression… of gene function, stem cell gene transfer, gene therapy for …
optimizing transgene expression… of gene function, stem cell gene transfer, gene therapy for …