Thioesterase superfamily member 1 (Them1) is an acyl-CoA thioesterase that is highly
expressed in brown adipose tissue, where it functions to suppress energy expenditure.
Lower Them1 expression levels in the liver are upregulated in response to high-fat feeding.
Them1−/− mice are resistant to diet-induced obesity, hepatic steatosis, and glucose
intolerance, but the contribution of Them1 in liver is unclear. To examine its liver-specific
functions, we created conditional transgenic mice, which, when bred to Them1−/− mice and …