Regulation of galanin gene expression in the hypothalamic paraventricular nucleus of the obese Zucker rat by manipulation of dietary macronutrients
JG Mercer, CB Lawrence, T Atkinson - Molecular brain research, 1996 - Elsevier
Lean and obese male Zucker rats were fed high fat (72% of energy as fat), high
carbohydrate (66% of energy as carbohydrate) or intermediate diets for 4 weeks
commencing 1 week after weaning. We examined the effects of these diets on growth rates,
plasma insulin and corticosterone titres, and hypothalamic gene expression of 3 appetite-
related neuropeptides. Messenger RNA levels for neuropeptide Y (NPY), galanin (GAL) and
corticotropin-releasing factor (CRF) in critical hypothalamic locations were measured by in …
carbohydrate (66% of energy as carbohydrate) or intermediate diets for 4 weeks
commencing 1 week after weaning. We examined the effects of these diets on growth rates,
plasma insulin and corticosterone titres, and hypothalamic gene expression of 3 appetite-
related neuropeptides. Messenger RNA levels for neuropeptide Y (NPY), galanin (GAL) and
corticotropin-releasing factor (CRF) in critical hypothalamic locations were measured by in …
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