Regulation of p53, nuclear factor κB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin
N Kalra, K Bhui, P Roy, S Srivastava, J George… - Toxicology and applied …, 2008 - Elsevier
Bromelain is a pharmacologically active compound, present in stems and immature fruits of
pineapples (Ananas cosmosus), which has been shown to have anti-edematous, anti-
inflammatory, anti-thrombotic and anti-metastatic properties. In the present study,
antitumorigenic activity of bromelain was recorded in 7, 12-dimethylbenz (a) anthracene
(DMBA)-initiated and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted 2-stage mouse
skin model. Results showed that bromelain application delayed the onset of tumorigenesis …
pineapples (Ananas cosmosus), which has been shown to have anti-edematous, anti-
inflammatory, anti-thrombotic and anti-metastatic properties. In the present study,
antitumorigenic activity of bromelain was recorded in 7, 12-dimethylbenz (a) anthracene
(DMBA)-initiated and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted 2-stage mouse
skin model. Results showed that bromelain application delayed the onset of tumorigenesis …
Regulation of p53, nuclear factor κB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin.
NK Neetu Kalra, KB Kulpreet Bhui, PR Preeti Roy… - 2008 - cabidigitallibrary.org
Bromelain is a pharmacologically active compound, present in stems and immature fruits of
pineapples (Ananas cosmosus), which has been shown to have anti-edematous, anti-
inflammatory, anti-thrombotic and anti-metastatic properties. In the present study,
antitumorigenic activity of bromelain was recorded in 7, 12-dimethylbenz (a) anthracene
(DMBA)-initiated and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted 2-stage mouse
skin model. Results showed that bromelain application delayed the onset of tumorigenesis …
pineapples (Ananas cosmosus), which has been shown to have anti-edematous, anti-
inflammatory, anti-thrombotic and anti-metastatic properties. In the present study,
antitumorigenic activity of bromelain was recorded in 7, 12-dimethylbenz (a) anthracene
(DMBA)-initiated and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted 2-stage mouse
skin model. Results showed that bromelain application delayed the onset of tumorigenesis …
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