Regulon-specific control of transcription elongation across the yeast genome
V Pelechano, S Jimeno-Gonzalez… - PLoS …, 2009 - journals.plos.org
Transcription elongation by RNA polymerase II was often considered an invariant non-
regulated process. However, genome-wide studies have shown that transcriptional pausing
during elongation is a frequent phenomenon in tightly-regulated metazoan genes. Using a
combination of ChIP-on-chip and genomic run-on approaches, we found that the proportion
of transcriptionally active RNA polymerase II (active versus total) present throughout the
yeast genome is characteristic of some functional gene classes, like those related to …
regulated process. However, genome-wide studies have shown that transcriptional pausing
during elongation is a frequent phenomenon in tightly-regulated metazoan genes. Using a
combination of ChIP-on-chip and genomic run-on approaches, we found that the proportion
of transcriptionally active RNA polymerase II (active versus total) present throughout the
yeast genome is characteristic of some functional gene classes, like those related to …
Regulon-specific control of transcription elongation across the yeast genome
VJ Pelechano García, S Jimeno-González… - … , 2009, vol. 5, num. 8, p …, 2009 - rodrigo.uv.es
Transcription elongation by RNA polymerase II was often considered an invariant non-
regulated process. However, genome-wide studies have shown that transcriptional pausing
during elongation is a frequent phenomenon in tightly-regulated metazoan genes. Using a
combination of ChIP-on-chip and genomic run-on approaches, we found that the proportion
of transcriptionally active RNA polymerase II (active versus total) present throughout the
yeast genome is characteristic of some functional gene classes, like those related to …
regulated process. However, genome-wide studies have shown that transcriptional pausing
during elongation is a frequent phenomenon in tightly-regulated metazoan genes. Using a
combination of ChIP-on-chip and genomic run-on approaches, we found that the proportion
of transcriptionally active RNA polymerase II (active versus total) present throughout the
yeast genome is characteristic of some functional gene classes, like those related to …
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