Relationship between Hounsfield units of upper instrumented vertebrae, proximal junctional failure, and global alignment and proportion score in female patients with …
Study Design This was a retrospective observational study. Objectives The purpose of this
study was to evaluate bone mineral density using Hounsfield unit (HU) values at the upper
instrumented vertebrae (UIV), UIV+ 1, and UIV+ 2 and to investigate the association with
proximal junctional failure (PJF) in female patients with adult spinal deformity (ASD). We
also evaluated the relationship between the global alignment and proportion (GAP) score
and the HU value of patients after ASD surgery. Methods Fifty-two patients (52 females …
study was to evaluate bone mineral density using Hounsfield unit (HU) values at the upper
instrumented vertebrae (UIV), UIV+ 1, and UIV+ 2 and to investigate the association with
proximal junctional failure (PJF) in female patients with adult spinal deformity (ASD). We
also evaluated the relationship between the global alignment and proportion (GAP) score
and the HU value of patients after ASD surgery. Methods Fifty-two patients (52 females …
Study Design
This was a retrospective observational study.
Objectives
The purpose of this study was to evaluate bone mineral density using Hounsfield unit (HU) values at the upper instrumented vertebrae (UIV), UIV+1, and UIV+2 and to investigate the association with proximal junctional failure (PJF) in female patients with adult spinal deformity (ASD). We also evaluated the relationship between the global alignment and proportion (GAP) score and the HU value of patients after ASD surgery.
Methods
Fifty-two patients (52 females, mean age =70.2 years) who underwent multiple-level lateral lumbar interbody fusion combined with posterior instrumentation for ASD were included. The patients were divided into 2 groups, PJF and non-PJF. The demographics, surgical characteristics, and radiographic parameters were compared. Vertebral HU values at UIV, UIV+1, and UIV+2 using preoperative computed tomography scans and immediate postoperative GAP scores were also compared.
Results
PJF was found in 13 of 52 patients (25.0%). Preoperative and postoperative thoracic kyphosis was large in PJF patients. Based on the total GAP score, there was no significant difference among the categories of GAP scores (P = 0.514). The statistically significant difference in mean HU values (116.6 ± 28.1 vs. 141.8 ± 41.8, P = 0.049) between the two groups at UIV. Further correlation analysis showed that the mean HU values in UIV and UIV+1 showed a significantly negative correlation coefficient with the total GAP score.
Conclusions
Our study suggests that preoperative HU values at UIV may affect the development of PJF for female ASD patients. HU evaluation by preoperative computed tomography may help reduce the incidence of PJF.
Elsevier
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