High visceral adiposity and intramyocellular lipid levels (IMCL) are both associated with the
development of type 2 diabetes. The relationship between visceral adiposity and IMCL
levels was explored in diet-and glucocorticoid-induced models of insulin resistance. In the
diet-induced model, lean and fa/fa Zucker rats were fed either normal or high-fat (HF) chow
over 4 wk. Fat distribution, IMCL content in the tibialis anterior (TA) muscle (IMCLTA), and
whole body insulin resistance were measured before and after the 4-wk period. The HF diet …

High visceral adiposity and intramyocellular lipid levels (IMCL) are both associated with the
development of type 2 diabetes. The relationship between visceral adiposity and IMCL
levels was explored in a diet-induced and a glucocorticoid-induced model of insulin
resistance. In the diet-induced model, lean and fa/fa Zucker rats were fed either a normal or
a high-fat (HF) chow over a 4-week period. Fat distribution, IMCL content in the tibialis
anterior (IMCLTA) muscle and whole-body insulin resistance were measured prior to and …