Reliability and role of mutation-specific H3F3A (Histone 3-3) G34W immunohistochemistry to differentiate giant cell tumor of bone from its clinicoradiologic and …
Giant cell tumor of bone (GCTB) is a benign neoplasm, which can sometimes be a
diagnostic challenge, especially in small biopsies, due to its histologic benign and malignant
mimics. We evaluated the role of H3. 3 G34W immunohistochemistry (IHC) antibody in
diagnosing GCTB and its role in differentiating it from its close histologic mimics. A total of
120 cases (80 cases of GCTB and 40 cases of histologic mimics) were retrieved and
subjected to IHC. Of 80 cases of GCTB, 72 cases showed a positive nuclear …
diagnostic challenge, especially in small biopsies, due to its histologic benign and malignant
mimics. We evaluated the role of H3. 3 G34W immunohistochemistry (IHC) antibody in
diagnosing GCTB and its role in differentiating it from its close histologic mimics. A total of
120 cases (80 cases of GCTB and 40 cases of histologic mimics) were retrieved and
subjected to IHC. Of 80 cases of GCTB, 72 cases showed a positive nuclear …
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