Spermatogonial stem cells reside in specific niches within seminiferous tubules and
continuously generate differentiating daughter cells for production of spermatozoa. Although
spermatogonial stem cells are unipotent, these cells are able to spontaneously convert to
germline cell–derived pluripotent stem cells (GPSCs) in vitro. GPSCs have many properties
of embryonic stem cells and are highly plastic, but their therapeutic potential in tissue
regeneration has not been fully explored. Using a novel renal epithelial differentiation …