Reporter genes facilitating discovery of drugs targeting protozoan parasites

A Dube, R Gupta, N Singh - Trends in parasitology, 2009 - cell.com
Transfection of protozoan parasites, such as Plasmodium, Leishmania, Trypanosoma and
Toxoplasma, with various reporter gene constructs, has revolutionized studies to understand
the biology of the host–parasite interactions at the cellular level. It has provided impetus to
the development of rapid and reliable drug screens both for established drugs and for new
molecules against different parasites and other pathogens. Furthermore, reporter genes
have proved to be an excellent and promising tool for studying disease progression. Here …

Reporter genes facilitating discovery of drugs targeting protozoan parasites.

AD Anuradha Dube, RG Reema Gupta… - 2009 - cabidigitallibrary.org
Transfection of protozoan parasites, such as Plasmodium, Leishmania, Trypanosoma and
Toxoplasma, with various reporter gene constructs, has revolutionized studies to understand
the biology of the host-parasite interactions at the cellular level. It has provided impetus to
the development of rapid and reliable drug screens both for established drugs and for new
molecules against different parasites and other pathogens. Furthermore, reporter genes
have proved to be an excellent and promising tool for studying disease progression. Here …
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