… In this study, we repurposed the sensor to be able to deliver an antimicrobial payload upon
V. cholerae detection. In line with this approach, we adapted the “sense, lyse, and release” …

… and structural biology have repurposed TCSs for applications … However, the utility of many
TCS biosensors is hindered by … cholerae-sensing CqsS-LuxU-LuxO-based TCS biosensor in …

… cholerae TcpP cholate sensing module is fused to the DBD of CadC to build a TCS in … A
chimeric twocomponent regulatory system-based Escherichia coli biosensor engineered to …

… cholerae biosensor working principle when the circuit is activated … Next, the integration of the
biosensor with killing peptide is … cholerae, with most of them being based on two component …

… coli biosensor to detect and kill Vibrio cholerae based on a cholera autoinducer-1 (CAI-1)
and the cqs-lux system, which could be potentially used for preventing and treating …

… -derived CqsS and the native NisKR two-component signaling system. (c) NarX–NarL and
ThsS… Repurposing a two-component system-based biosensor for the killing of Vibrio cholerae. …

… living whole-cell biosensors with robust genetic circuits that … et al. built a two-component
hybrid receptor that consisted of … In a later study the authors repurposed their system to sense …

… pathways, by repurposing naturally occurring proteins and by … and mammalian cells as
living biosensors 4 that can be … The tetrathionate sensor is based on a two-component TtrR/…

… TCS can be repurposed to generate cell-based biosensors (Figure 4). For example, … Vibrio
cholerae to design a sense-and-killing device [95]. Other researchers generated biosensors …

… genetic repurposing. One such example involves the identification of a synthetic biosensor
… aeruginosa-killing engineered microbes, microbes engineered to suppress the virulence of …