Research ethics and the challenge of whole-genome sequencing

AL McGuire, T Caulfield, MK Cho - Nature Reviews Genetics, 2008 - nature.com
ethical considerations. We propose specific recommendations for each of these ethically
controversial issues, which can be used to guide research practice and stimulate policy …

Research ethics recommendations for whole-genome research: consensus statement

T Caulfield, AL McGuire, M Cho, JA Buchanan… - … biology, 2008 - journals.plos.org
… We therefore convened an interdisciplinary consensus workshop to develop ethically
rigorous and practical guidance for investigators and research ethics boards. What follows …

Ethical implications of the use of whole genome methods in medical research

J Kaye, P Boddington, J De Vries, N Hawkins… - European Journal of …, 2010 - nature.com
… such as whole genome sequencing methods is that it takes some time before a critical amount
of expertise is built up within the research ethics community to make approval for research

Informed consent for whole-genome sequencing studies in the clinical setting. Proposed recommendations on essential content and process

C Ayuso, JM Millán, M Mancheno… - European Journal of …, 2013 - nature.com
statements. The following search strategy was used: (… OR whole-genome sequencing
OR whole genome sequencing … Consent OR consent) OR (Ethics OR ethical issues) OR (incidental …

Genomics really gets personal: how exome and whole genome sequencing challenge the ethical framework of human genetics research

HK Tabor, BE Berkman, SC Hull… - American Journal of …, 2011 - Wiley Online Library
… as to highlight the opportunities for the research, ethics and policy communities to … ethical
practices of existing or published ES/WGS studies or to make specific policy recommendations

Ethical issues raised by whole genome sequencing

W Pinxten, HC Howard - Best Practice & Research Clinical …, 2014 - Elsevier
… Such an approach is consistent with the history of research ethics with human subjects. …
recommends that clinical sequencing laboratories have a duty, when performing whole genome

Ethical and legal implications of whole genome and whole exome sequencing in African populations

GEB Wright, PGJ Koornhof, AA Adeyemo, N Tiffin - BMC Medical Ethics, 2013 - Springer
research subjects typically require ethical clearance from relevant institutional review boards
(IRBs) or research ethics … raised in this study as well as potential recommendations to help …

Findings made in gene panel to whole genome sequencing: data, knowledge, ethics–and consequences?

EC Winkler, S Wiemann - Expert review of molecular diagnostics, 2016 - Taylor & Francis
… Diverse kinds of sequencing approaches are applied, ranging from gene panel to whole-genome
sequencing. All these have proven successful in the identification of causal and …

[HTML][HTML] Stakeholder views on secondary findings in whole-genome and whole-exome sequencing: a systematic review of quantitative and qualitative studies

MP Mackley, B Fletcher, M Parker, H Watkins… - Genetics in …, 2017 - Elsevier
… for the ACMG recommendations, opponents (and alternative guidelines from Europe and …
diseases in Canada: Position Statement of the Canadian College of Medical Geneticists …

Ethical and practical guidelines for reporting genetic research results to study participants: updated guidelines from a National Heart, Lung, and Blood Institute working …

RR Fabsitz, A McGuire, RR Sharp… - Circulation …, 2010 - Am Heart Assoc
… of a conference report and recommendations on returning genetic research results to … 4
High-throughput technologies have been developed, whole genome sequencing is a reality, …