Stimulation of retinal photoreceptors with elevated glucose concentration (30 mM) for 96 h,
served as diabetic retinopathy in vitro model to study Resolvin D1 (50 nM) effects on
neovascularization. VEGF and anti-angiogenic miR-20a-3p, miR-20a-5p, miR-106a-5p, and
miR-20b expression was assessed either in photoreceptors exposed to HG or in exosomes
released by those cells. High glucose increased VEGF levels and concurrently decreased
anti-angiogenic miRNAs content in photoreceptors and exosomes. RvD1 reverted the effects …

1 Section of Pharmacology, Department of Experimental Medicine, University of Campania
“Luigi Vanvitelli”, Naples, Italy, 2 Department of Experimental Medicine, University of
Campania “Luigi Vanvitelli”, Naples, Italy, 3 Multidisciplinary Department of Surgical and
Dental Specialties, University of Campania “Luigi Vanvitelli”, Naples, Italy, 4 Department of
Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy, 5 Department of
Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples …