Retinoic acid-induced differentiation increases the rate of oxygen consumption and enhances the spare respiratory capacity of mitochondria in SH-SY5Y cells
Retinoic acid (RA) is used in differentiation therapy to treat a variety of cancers including
neuroblastoma. The contributing factors for its therapeutic efficacy are poorly understood.
However, mitochondria (MT) have been implicated as key effectors in RA-mediated
differentiation process. Here we utilize the SH-SY5Y human neuroblastoma cell line as a
model to examine how RA influences MT during the differentiation process. We find that RA
confers an approximately sixfold increase in the oxygen consumption rate while the rate of …
neuroblastoma. The contributing factors for its therapeutic efficacy are poorly understood.
However, mitochondria (MT) have been implicated as key effectors in RA-mediated
differentiation process. Here we utilize the SH-SY5Y human neuroblastoma cell line as a
model to examine how RA influences MT during the differentiation process. We find that RA
confers an approximately sixfold increase in the oxygen consumption rate while the rate of …
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