OBJECTIVES: Adalimumab, an anti-tumor necrosis factor immunoglobulin-1 antibody, is
increasingly being reported as a potential treatment option for children with moderate-to-
severe Crohn's disease (CD). The aim of this study was to characterize common indications,
safety, tolerability, and clinical response to adalimumab in pediatric CD in a large,
multicenter, patient cohort. METHODS: Data were obtained using a retrospective,
uncontrolled chart review at 12 sites of the Pediatric Inflammatory Bowel Disease …

Background: People with CD have an increased risk of low bone mineral density,
osteopenia, osteoporosis and vitamin D deficiency. The aim of this the study was to assess
serum vitamin D status in non-hospitalised adult CD patients and to explore associated
factors. Methods: This was a prospective cross-sectional study in which comprehensive
nutritional, clinical and biochemical assessments were performed on 81 CD patients and 81
age-, sex-and socioeconomic matched healthy controls. Serum 25-hydroxyvitamin D was …