… In this study, we have demonstrated the ribosomal synthesis of peptides containing multiple
N-methyl backbone modifications. Our approach relies on supplementing PURE system …

… coli ribosomes that enable enhanced peptide/protein incorporation of certain N-methyl amino
… factor P (EF-P) on peptide/protein synthesis yields. Of particular note is the computational …

… Natural peptide products often contain N-methylated … peptides peptidase resistant and
membrane permeable. Here, we demonstrate the ribosomal synthesis of N-methyl-peptides by …

… Here, we have demonstrated the selection of anti-E6AP macrocyclic N-methyl-peptides, one
… E6AP macrocyclic N-methyl-peptides, and one of the abundant classes of selected peptides …

… motifs observed in PNPs into peptides. In this review, we will … the ribosomal synthesis of
natural product-like peptides using … N-methyl amino acids were included during the preparation …

… N-methyl-peptides with three or four Ν-methylated backbone residues could be
synthesized… This work has opened the possibility of the mRNA-encoded synthesis of N-methyl-peptide …

… domain of module 2 with an N-methyl valine (MeVal) activation … can catalyze peptide-bond
formation between N-methyl and … Steric hindrance reduces chemical reactivity of N-methyl …

… Despite the fact that N-methyl-α-amino acids are … peptide chain using the classical
amber suppression method, (5) we and other groups recently found that nearly a dozen N-methyl-α-…

… in studying ribosomal incorporations of N-methyl amino acids (… (3)N-Methylation of the
peptide backbone improves … Ribosomal synthesis of such peptides allows genetic encoding of …

… Nonetheless, this study shows the possibility of using OphMA for introducing N-methyl groups
in non-native substrates. In addition, the cyanobactin prenyltransferases have been shown …