Polymerization-induced self-assembly (PISA) has simplified the preparation of polymeric
nanoparticles, expanding their commercial importance. Recently, PISA mediated via ring-
opening metathesis polymerization (ROMPISA) has emerged as a powerful alternative to
existing PISA methodologies. ROMPISA can be conducted under air in minutes, producing
nano-object morphologies with unique characteristics. Herein, we highlight recent advances
in this field.

We report the one-pot aqueous phase synthesis of cisplatin drug loaded micellar
nanoparticles using Ring-Opening Metathesis Polymerization-Induced Self-Assembly
(ROMPISA). ROMPISA was used to generate a small library of nanoparticles to examine the
effect of size and charge on their action as cytotoxic agents against human ovarian and
cervical cancer cells in vitro. The results show that polymerization-induced self-assembly
(PISA) can easily yield drug loaded nanoparticles in one step at high solids concentrations …