Rodent, large animal and non-human primate models of spinal cord injury

R Nardone, C Florea, Y Höller, F Brigo, V Versace… - Zoology, 2017 - Elsevier
In this narrative review we aimed to assess the usefulness of the different animal models in
identifying injury mechanisms and developing therapies for humans suffering from spinal
cord injury (SCI). Results obtained from rodent studies are useful but, due to the anatomical,
molecular and functional differences, confirmation of these findings in large animals or non-
human primates may lead to basic discoveries that cannot be made in rodent models and
that are more useful for developing treatment strategies in humans. SCI in dogs can be …

[PDF][PDF] Rodent, large animal and non-human primate models of

R Nardone, C Florea, Y Höller - Exp. Neurol, 2017 - academia.edu
In this narrative review we aimed to assess the usefulness of the different animal models in
identifying injury mechanisms and developing therapies for humans suffering from spinal
cord injury (SCI). Results obtained from rodent studies are useful but, due to the anatomical,
molecular and functional differences, confirmation of these findings in large animals or non-
human primates may lead to basic discoveries that cannot be made in rodent models and
that are more useful for developing treatment strategies in humans. SCI in dogs can be …
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