Role of interleukin-6 and interleukin-10 in morphological and functional changes of the blood–brain barrier in hypertriglyceridemia
Background Hypertriglyceridemia is closely linked to atherosclerosis related inflammatory
processes and blood–brain barrier (BBB) dysfunction. Using apolipoprotein B-100 (APOB-
100) transgenic mice, an animal model of chronic hypertriglyceridemia, we analyzed BBB
function and morphology in vitro and ex vivo. Our objective was to determine which BBB
characteristics are produced mainly by interleukin (IL)-6, an atherosclerosis promoting
cytokine, and whether these actions can be antagonized by IL-10, an anti-inflammatory …
processes and blood–brain barrier (BBB) dysfunction. Using apolipoprotein B-100 (APOB-
100) transgenic mice, an animal model of chronic hypertriglyceridemia, we analyzed BBB
function and morphology in vitro and ex vivo. Our objective was to determine which BBB
characteristics are produced mainly by interleukin (IL)-6, an atherosclerosis promoting
cytokine, and whether these actions can be antagonized by IL-10, an anti-inflammatory …
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