Cellular and molecular aspects of contractile dysfunction in heart failure
C Mittmann, T Eschenhagen… - Cardiovascular research, 1998 - academic.oup.com
… in heart failure could theoretically affect the calcium sensitivity of … role of the extracellular
matrix for diastolic function in heart failure and the changes in chamber stiffness and myocardial …
matrix for diastolic function in heart failure and the changes in chamber stiffness and myocardial …
Altered function and regulation of cardiac ryanodine receptors in cardiac disease
XHT Wehrens, AR Marks - Trends in biochemical sciences, 2003 - cell.com
… Thus, defects in RyR2 have been linked to heart failure and exercise-induced sudden cardiac
… (b) To enable relaxation, intracellular Ca 2+ is pumped out of the cytoplasm by the SR …
… (b) To enable relaxation, intracellular Ca 2+ is pumped out of the cytoplasm by the SR …
Myocardial dysfunction and abnormalities in intracellular calcium handling in obese rats
AP Lima-Leopoldo, AS Leopoldo… - Arquivos Brasileiros …, 2011 - SciELO Brasil
… OBJECTIVE: The purpose of this study was to investigate … cardiac dysfunction by changes
in intracellular Ca 2+ handling, probably by reduced cardiac sarcoplasmic reticulum Ca 2+ …
in intracellular Ca 2+ handling, probably by reduced cardiac sarcoplasmic reticulum Ca 2+ …
Differential regulation of two types of intracellular calcium release channels during end-stage heart failure.
LO Go, MC Moschella, J Watras… - The Journal of …, 1995 - Am Soc Clin Investig
… cardiac muscle is calcium-induced calcium release via the RyR (4, 5), evidence has
accumulated supporting a role for IP3-induced calcium … in progressive myocardial dysfunction. …
accumulated supporting a role for IP3-induced calcium … in progressive myocardial dysfunction. …
The relationship between arrhythmogenesis and impaired contractility in heart failure: role of altered ryanodine receptor function
… + handling has been implicated in cardiac arrhythmias and contractile dysfunction. … Ca 2+
handling, we measured intracellular Ca 2+ transients in isolated intact field-stimulated cardiac …
handling, we measured intracellular Ca 2+ transients in isolated intact field-stimulated cardiac …
Abnormalities in intracellular Ca2+ regulation contribute to the pathomechanism of Tako-Tsubo cardiomyopathy
… overstimulation contributing to myocardial dysfunction could be … that an altered Ca 2+ cycling
plays a dominant role in the … , myocardial infarction, valvular heart disease, or heart failure. …
plays a dominant role in the … , myocardial infarction, valvular heart disease, or heart failure. …
Role of NOD1 in Heart Failure Progression via Regulation of Ca2+ Handling
A Val-Blasco, MJGM Piedras, G Ruiz-Hurtado… - … college of cardiology, 2017 - jacc.org
… systolic Ca 2+ release and SR Ca 2+ load, underlying the depressed cardiac function of wt
… exhibited an ameliorated cardiac dysfunction via an intracellular Ca 2+ handling mechanism (…
… exhibited an ameliorated cardiac dysfunction via an intracellular Ca 2+ handling mechanism (…
Mechanisms of impaired calcium handling underlying subclinical diastolic dysfunction in diabetes
VA Lacombe, S Viatchenko-Karpinski… - American Journal …, 2007 - journals.physiology.org
… dysfunction is associated with impaired myocardial Ca 2+ … the risk of heart failure in diabetic
patients, despite preserved … -induced intracellular Ca 2+ transients as a function of voltage in …
patients, despite preserved … -induced intracellular Ca 2+ transients as a function of voltage in …
SERCA2a: a key protein in the Ca2+ cycle of the heart failure
L Zhihao, N Jingyu, L Lan, S Michael, G Rui, B Xiyun… - Heart failure …, 2020 - Springer
… Disorders of SR function lead to the dysfunction of Ca 2+ … conditions for the transient
increase of intracellular Ca 2+ . … improved cardiac function in dilated heart disease mice and …
increase of intracellular Ca 2+ . … improved cardiac function in dilated heart disease mice and …
Contribution of abnormal sarcoplasmic reticulum ATPase activity to systolic and diastolic dysfunction in human heart failure
U Schmidt, RJ Hajjar, PA Helm, CS Kim… - … and cellular cardiology, 1998 - Elsevier
… We measured the systolic and diastolic intracellular calcium concentration in isolated …
importance for force development and intracellular calcium concentrations in human myocardium. …
importance for force development and intracellular calcium concentrations in human myocardium. …