Role of the DRM and CMT3 methyltransferases in RNA-directed DNA methylation
X Cao, W Aufsatz, D Zilberman, MF Mette, MS Huang… - Current biology, 2003 - cell.com
RNA interference is a conserved process in which double-stranded RNA is processed into
21–25 nucleotide siRNAs that trigger posttranscriptional gene silencing. In addition, plants
display a phenomenon termed RNA-directed DNA methylation (RdDM) in which DNA with
sequence identity to silenced RNA is de novo methylated at its cytosine residues. This
methylation is not only at canonical CpG sites but also at cytosines in CpNpG and
asymmetric sequence contexts. In this report, we study the role of the DRM and CMT3 DNA …
21–25 nucleotide siRNAs that trigger posttranscriptional gene silencing. In addition, plants
display a phenomenon termed RNA-directed DNA methylation (RdDM) in which DNA with
sequence identity to silenced RNA is de novo methylated at its cytosine residues. This
methylation is not only at canonical CpG sites but also at cytosines in CpNpG and
asymmetric sequence contexts. In this report, we study the role of the DRM and CMT3 DNA …
Role of the DRM and CMT3 methyltransferases in RNA-directed DNA methylation.
CXF Cao XiaoFeng, W Aufsatz, D Zilberman, MF Mette… - 2003 - cabidigitallibrary.org
RNA interference is a conserved process in which double-stranded RNA is processed into
21-25 nucleotide siRNAs that trigger posttranscriptional gene silencing. In addition, plants
display a phenomenon termed RNA-directed DNA methylation (RdDM) in which DNA with
sequence identity to silenced RNA is de novo methylated at its cytosine residues. This
methylation is not only at canonical CpG sites but also at cytosines in CpNpG and
asymmetric sequence contexts. In this report, we study the role of the DRM and CMT3 DNA …
21-25 nucleotide siRNAs that trigger posttranscriptional gene silencing. In addition, plants
display a phenomenon termed RNA-directed DNA methylation (RdDM) in which DNA with
sequence identity to silenced RNA is de novo methylated at its cytosine residues. This
methylation is not only at canonical CpG sites but also at cytosines in CpNpG and
asymmetric sequence contexts. In this report, we study the role of the DRM and CMT3 DNA …
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