[HTML][HTML] Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission
… The K-Cl co-transporter KCC2 plays multiple roles in the physiology of central neurons and
alterations of its function … By regulating intraneuronal chloride homeostasis, KCC2 strongly …
alterations of its function … By regulating intraneuronal chloride homeostasis, KCC2 strongly …
K-Cl cotransporter KCC2—a moonlighting protein in excitatory and inhibitory synapse development and function
P Blaesse, T Schmidt - Pflügers Archiv-European Journal of Physiology, 2015 - Springer
… The K-Cl cotransporter KCC2 has two entirely independent biological actions as either an
… KCC2 plays a crucial role in dendritic spine formation Studies on neuronal K-Cl cotransport …
… KCC2 plays a crucial role in dendritic spine formation Studies on neuronal K-Cl cotransport …
GABA Neurotransmission and Neural Cation-Chloridec Co-transporters: Actions Beyond Ion Transport
I Medina, I Chudotvorova - Critical Reviews™ in Neurobiology, 2006 - dl.begellhouse.com
… : Na+-K+—2 Cl– and K+—Cl–, respectively. Each co-transporter can potentially move ions in
either … : both NKCC1 and KCC2 play a critical role in the formation of the neuronal network. …
either … : both NKCC1 and KCC2 play a critical role in the formation of the neuronal network. …
K+-Cl− co-transporter 2 (KCC2) – a membrane trafficking perspective
BL Tang - Molecular Membrane Biology, 2016 - Taylor & Francis
… K + -Cl − co-transporter 2 (KCC2/SLC12A5) is a neuronal … and glycine to exert inhibitory
neurotransmission through its Cl − … This developmental excitatory-inhibitory switch has important …
neurotransmission through its Cl − … This developmental excitatory-inhibitory switch has important …
[HTML][HTML] Current view on the functional regulation of the neuronal K+-Cl− cotransporter KCC2
I Medina, P Friedel, C Rivera, KT Kahle… - Frontiers in cellular …, 2014 - frontiersin.org
… of the electroneutral K + -Cl − cotransporter KCC2, a member of the … Cl − homeostasis and
GABAergic neurotransmission. As … in KCC2 functional expression after prolonged inhibition of …
GABAergic neurotransmission. As … in KCC2 functional expression after prolonged inhibition of …
Crossing the Chloride Channel: The Current and Potential Therapeutic Value of the Neuronal K+‐Cl- Cotransporter KCC2
L Tillman, J Zhang - BioMed research international, 2019 - Wiley Online Library
… This constitutes the main role of GABA in CNS neurotransmission; its potential dysfunction
… of the neuron-specific K–Cl cotransporter KCC2. The mouse KCC2 co-transporter consists of …
… of the neuron-specific K–Cl cotransporter KCC2. The mouse KCC2 co-transporter consists of …
Cation-chloride cotransporters in neuronal communication
E Delpire - Physiology, 2000 - journals.physiology.org
… neurons that use glycine as an inhibitory neurotransmitter, a … (excitatory) responses, but
later it produces hyperpolarizing (… in expression of the K + -Cl – cotransporter KCC2. These …
later it produces hyperpolarizing (… in expression of the K + -Cl – cotransporter KCC2. These …
[HTML][HTML] Cation-chloride cotransporters KCC2 and NKCC1 as therapeutic targets in neurological and neuropsychiatric disorders
P Lam, J Newland, RLM Faull, A Kwakowsky - Molecules, 2023 - mdpi.com
… inhibitory NT in intrinsic neurons of the brain where it acts to regulate excitatory neurotransmission
[… In isotonic conditions, KCC2 maintains K-Cl cotransport due to its unique C-terminal …
[… In isotonic conditions, KCC2 maintains K-Cl cotransport due to its unique C-terminal …
Modulation of neuronal activity by phosphorylation of the K–Cl cotransporter KCC2
KT Kahle, TZ Deeb, M Puskarjov, L Silayeva… - Trends in …, 2013 - cell.com
… K–Cl cotransporter KCC2 establishes the low intraneuronal Cl – levels required for the
hyperpolarizing inhibitory … phosphorylation have been associated with impaired KCC2 function in …
hyperpolarizing inhibitory … phosphorylation have been associated with impaired KCC2 function in …
Chloride transporters controlling neuronal excitability
JC Pressey, M de Saint-Rome… - Physiological …, 2023 - journals.physiology.org
… that the neuron-specific K + -Cl − cotransporter (KCC2) was … their involvement in inhibitory
neurotransmission further, but … As we explain below, GABA can be excitatory or inhibitory …
neurotransmission further, but … As we explain below, GABA can be excitatory or inhibitory …