S2431 Ulcerative Colitis Flare-Ups Following MRNA COVID-19 Vaccination
Official journal of the American College of Gastroenterology| ACG, 2021•journals.lww.com
Discussion: To our best knowledge, no report has shown the association of mRNA vaccine
and UC flare-up. In general, non-live vaccines are safe for UC patients regardless of
immunosuppressants usage. Live vaccines are also contraindicated Tofacitinib users like
our patient. In the Pfizer COVID-19 vaccine trial, patients on immunosuppressive therapy
were excluded. Given the temporal relationship between the vaccine and her flare-up in the
setting of long-term remission history, we are concerned that the stress induced by the …
and UC flare-up. In general, non-live vaccines are safe for UC patients regardless of
immunosuppressants usage. Live vaccines are also contraindicated Tofacitinib users like
our patient. In the Pfizer COVID-19 vaccine trial, patients on immunosuppressive therapy
were excluded. Given the temporal relationship between the vaccine and her flare-up in the
setting of long-term remission history, we are concerned that the stress induced by the …
Discussion:
To our best knowledge, no report has shown the association of mRNA vaccine and UC flare-up. In general, non-live vaccines are safe for UC patients regardless of immunosuppressants usage. Live vaccines are also contraindicated Tofacitinib users like our patient. In the Pfizer COVID-19 vaccine trial, patients on immunosuppressive therapy were excluded. Given the temporal relationship between the vaccine and her flare-up in the setting of long-term remission history, we are concerned that the stress induced by the mRNA vaccine may increase the risk of flare-up. More studies need to be done to evaluate the safety profile of mRNA vaccine for UC patients on immunosuppressants. F1 Figure 1.:
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