Screening of topical gel containing lycopene and dexamethasone against UV radiation induced photoaging in mice

H Shah, SR Mahajan - Biomedicine & Aging Pathology, 2014 - Elsevier
Sun continuously emits UV radiation which produces series of pathological changes in the
body, in long term, this ultimately results in photoaging and skin cancer on long term.
Repeated UV exposure increases oxidative stress, nitrosative stress and inflammatory
mediators which lead to activation of p38, MMPs and results in photoaging. Lycopene is an
antioxidant and very low dose of dexamethasone provides anti-inflammatory effect. Animals
were applied with lycopene gel, dexamethasone gel and combination of dexamethasone …
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