Amalgam, IRM, and a mineral trioxide aggregate were tested for repair of experimentally created root perforations. Fifty sound, extracted mandibular and maxillary molars were used in this study. A perforation was created on the mesial root surface at about a 45-degree angle to the long axis of each tooth. The tooth was then placed into a salinesoaked “Oasis” to simulate a clinical condition. After placing the repair materials into the perforations, the teeth were kept for 4 wk in the Oasis model. The perforation sites were then stained with methylene blue for 48 h, sectioned, and examined under a dissecting microscope.

The results showed that the mineral trioxide aggregate had significantly less leakage than IRM or amalgam (p < 0.05). The mineral troxide aggregate also showed the least overfilling tendency while IRM showed the least underfilling tendency.