[HTML][HTML] Secondary Metabolism and Biotrophic Lifestyle in the Tomato Pathogen Cladosporium fulvum
J Collemare, S Griffiths, Y Iida, M Karimi Jashni… - PLoS …, 2014 - journals.plos.org
Cladosporium fulvum is a biotrophic fungal pathogen that causes leaf mould of tomato.
Analysis of its genome suggested a high potential for production of secondary metabolites
(SM), which might be harmful to plants and animals. Here, we have analysed in detail the
predicted SM gene clusters of C. fulvum employing phylogenetic and comparative genomic
approaches. Expression of the SM core genes was measured by RT-qrtPCR and produced
SMs were determined by LC-MS and NMR analyses. The genome of C. fulvum contains six …
Analysis of its genome suggested a high potential for production of secondary metabolites
(SM), which might be harmful to plants and animals. Here, we have analysed in detail the
predicted SM gene clusters of C. fulvum employing phylogenetic and comparative genomic
approaches. Expression of the SM core genes was measured by RT-qrtPCR and produced
SMs were determined by LC-MS and NMR analyses. The genome of C. fulvum contains six …
Secondary metabolism and biotrophic lifestyle in the tomato pathogen Cladosporium fulvum: from comparative genomics to reconstruction of biosynthetic pathways
JAR Collemare, SA Griffiths, R Cox… - 10th International …, 2014 - research.wur.nl
A fungal biotrophic lifestyle has been associated with a reduction of the potential for
production of secondary metabolites (SMs), which are in many cases toxic on the host
plants. Analysis of the genome of Cladosporium fulvum, a biotrophic fungal pathogen that
causes leaf mould of tomato, challenged this correlation. Indeed, C. fulvum shows a high
potential for SM production, including compounds toxic on plants such as elsinochrome, with
23 core genes (10 PKSs, 10 NRPSs, 2 hybrid PKS-NRPSs and 1 DMATS)[1]. However, we …
production of secondary metabolites (SMs), which are in many cases toxic on the host
plants. Analysis of the genome of Cladosporium fulvum, a biotrophic fungal pathogen that
causes leaf mould of tomato, challenged this correlation. Indeed, C. fulvum shows a high
potential for SM production, including compounds toxic on plants such as elsinochrome, with
23 core genes (10 PKSs, 10 NRPSs, 2 hybrid PKS-NRPSs and 1 DMATS)[1]. However, we …
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