Until recently, it was generally assumed that essentially all regulation of transcription takes
place via regions adjacent to the coding region of a gene—namely promoters and enhancers…

The androgen receptor (AR) signaling axis drives all stages of prostate cancer, including
the lethal, drug-resistant form of the disease termed castration-resistant prostate cancer (CRPC)…

Lineage plasticity is a hallmark of cancer and a critical facilitator of other oncogenic features
such as metastasis, therapy resistance, dysregulated metabolism, and immune evasion. It is …

The role of the androgen receptor (AR) in estrogen receptor (ER)-α-positive breast cancer is
controversial, constraining implementation of AR-directed therapies. Using a diverse, …

Metabolism alterations are hallmarks of cancer, but the involvement of lipid metabolism in
disease progression is unclear. We investigated the role of lipid metabolism in prostate cancer …

Geminivirus replication enhancer (REn) proteins dramatically increase the accumulation of
viral DNA species by an unknown mechanism. In this study, we present evidence implicating …

Circulating microRNAs (miRNAs) are emerging as useful non‐invasive markers of disease.
The objective of this study was to use a mouse model of prostate cancer as a tool to discover …

Androgen receptor (AR) variants (AR-Vs) expressed in prostate cancer (PCa) lack the AR
ligand binding domain (LBD) and function as constitutively active transcription factors. AR-V …

Background: Circulating microRNAs (miRNAs) are emerging as promising biomarkers for
prostate cancer. Here, we investigated the potential of these molecules to assist in prognosis …

Fatty acid β-oxidation (FAO) is the main bioenergetic pathway in human prostate cancer (PCa)
and a promising novel therapeutic vulnerability. Here we demonstrate therapeutic efficacy …