Sensitization of glioma cells to tamoxifen-induced apoptosis by Pl3-kinase inhibitor through the GSK-3β/β-catenin signaling pathway
C Li, C Zhou, S Wang, Y Feng, W Lin, S Lin, Y Wang… - PloS one, 2011 - journals.plos.org
Malignant gliomas represent one of the most aggressive types of cancers and their
recurrence is closely linked to acquired therapeutic resistance. A combination of
chemotherapy is considered a promising therapeutic model in overcoming therapeutic
resistance and enhancing treatment efficacy. Herein, we show by colony formation, Hochest
33342 and TUNEL staining, as well as by flow cytometric analysis, that LY294002, a specific
phosphatidylinositide-3-kinase (PI3K) inhibitor, enhanced significantly the sensitization of a …
recurrence is closely linked to acquired therapeutic resistance. A combination of
chemotherapy is considered a promising therapeutic model in overcoming therapeutic
resistance and enhancing treatment efficacy. Herein, we show by colony formation, Hochest
33342 and TUNEL staining, as well as by flow cytometric analysis, that LY294002, a specific
phosphatidylinositide-3-kinase (PI3K) inhibitor, enhanced significantly the sensitization of a …
以上显示的是最相近的搜索结果。 查看全部搜索结果