Sepsis is a major cause of mortality and morbidity in intensive care units. Organ dysfunction
is triggered by inflammatory insults and tissue hypoperfusion. The brain plays a pivotal role
in sepsis, acting as both a mediator of the immune response and a target for the pathologic
process. The measurement of brain dysfunction is difficult because there are no specific
biomarkers of neuronal injury, and bedside evaluation of cognitive performance is difficult in
an intensive care unit. Although sepsis-associated encephalopathy was described decades …