Sevoflurane therapy for life-threatening asthma in children
D Schutte, AM Zwitserloot, R Houmes… - British journal of …, 2013 - academic.oup.com
D Schutte, AM Zwitserloot, R Houmes, M de Hoog, JM Draaisma, J Lemson
British journal of anaesthesia, 2013•academic.oup.comBackground Asthma is a common disease in children and often develops early in life. This
multicentre retrospective case series describe the use and effectiveness of sevoflurane
inhalation therapy in a series of children with severe asthma in the paediatric intensive care
unit (PICU). Methods Seven children ranging from 4 to 13 yr of age admitted to the PICU of
two tertiary care hospitals in the Netherlands were included. They all were admitted with the
diag-nosis of severe asthma requiring invasive mechanical ventilation and were treated with …
multicentre retrospective case series describe the use and effectiveness of sevoflurane
inhalation therapy in a series of children with severe asthma in the paediatric intensive care
unit (PICU). Methods Seven children ranging from 4 to 13 yr of age admitted to the PICU of
two tertiary care hospitals in the Netherlands were included. They all were admitted with the
diag-nosis of severe asthma requiring invasive mechanical ventilation and were treated with …
Background
Asthma is a common disease in children and often develops early in life. This multicentre retrospective case series describe the use and effectiveness of sevoflurane inhalation therapy in a series of children with severe asthma in the paediatric intensive care unit (PICU).
Methods
Seven children ranging from 4 to 13 yr of age admitted to the PICU of two tertiary care hospitals in the Netherlands were included. They all were admitted with the diag-nosis of severe asthma requiring invasive mechanical ventilation and were treated with sevoflurane inhalation therapy.
Results
The median (range) Pco2 level at the start, after 2 h, and at the end of sevoflurane treatment were 14 (5.1–24.8), 9.8 (5.4–17.0), and 6.2 (4.5–11.4) kPa (P=0.05) while the median (range) pH was 7.02 (6.97–7.36), 7.18 (7.04–7.35), and 7.43 (7.15–7.47) kPa (P=0.01), respectively. The median (range) peak pressure values declined from 30 (23–56) to 20.4 (14–33) cm H2O (P=0.03). No severe adverse effects besides hypotension, with sufficient response to norepinephrine treatment, were seen.
Conclusions
Sevoflurane inhalation corrects high levels of Pco2 and provides clinical improvement in mechanically ventilated children with life-threatening asthma who fail to respond to conventional treatment.
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