Sex difference in enhancement of GGTase-positive foci by hexachlorobenzene and lindane in rat liver
MA Pereira, SL Herren, AL Britt, MM Khoury - Cancer Letters, 1982 - Elsevier
MA Pereira, SL Herren, AL Britt, MM Khoury
Cancer Letters, 1982•ElsevierThe ability of hexachlorobenzene and lindane in diethylnitrosamine (DENA) pretreated rats
to enhance the incidence of gamma-glutamyltrans-peptidase (GGTase)-positive foci was
determined. In rats that received either DENA followed by a basal agar diet or
hexachlorobenzene or lindane without prior administration of DENA, the incidence of
GGTase-positive foci was negligible. When hexachlorobenzene or lindane were
administered in the diet to rats that previously received DENA, there was an increased …
to enhance the incidence of gamma-glutamyltrans-peptidase (GGTase)-positive foci was
determined. In rats that received either DENA followed by a basal agar diet or
hexachlorobenzene or lindane without prior administration of DENA, the incidence of
GGTase-positive foci was negligible. When hexachlorobenzene or lindane were
administered in the diet to rats that previously received DENA, there was an increased …
The ability of hexachlorobenzene and lindane in diethylnitrosamine (DENA) pretreated rats to enhance the incidence of gamma-glutamyltrans-peptidase (GGTase)-positive foci was determined. In rats that received either DENA followed by a basal agar diet or hexachlorobenzene or lindane without prior administration of DENA, the incidence of GGTase-positive foci was negligible. When hexachlorobenzene or lindane were administered in the diet to rats that previously received DENA, there was an increased incidence of GGTase-positive foci that was greater in females than male rats and rats that received a 2 3 partial hepatectomy prior to the DENA. The results suggest that hepatocarcinogenicity of hexachlorobenzene and lindane results from tumor promotion.
Elsevier
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