Sex differences in the association of global amyloid and regional tau deposition measured by positron emission tomography in clinically normal older adults
Importance Mounting evidence suggests that sex differences exist in the pathologic
trajectory of Alzheimer disease. Previous literature shows elevated levels of cerebrospinal
fluid tau in women compared with men as a function of apolipoprotein E (APOE) ε4 status
and β-amyloid (Aβ). What remains unclear is the association of sex with regional tau
deposition in clinically normal individuals. Objective To examine sex differences in the cross-
sectional association between Aβ and regional tau deposition as measured with positron …
trajectory of Alzheimer disease. Previous literature shows elevated levels of cerebrospinal
fluid tau in women compared with men as a function of apolipoprotein E (APOE) ε4 status
and β-amyloid (Aβ). What remains unclear is the association of sex with regional tau
deposition in clinically normal individuals. Objective To examine sex differences in the cross-
sectional association between Aβ and regional tau deposition as measured with positron …
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