The potential role of metabolic impairments in the pathophysiology of depression is
motivating researchers to evaluate the treatment efficacy of creatine, a naturally occurring
energetic and neuroprotective compound found in brain and muscle tissues. Growing
evidence is demonstrating the benefit of oral creatine supplements for reducing depressive
symptoms in humans and animals. A novel question is whether dietary creatine, when
combined with antidepressant drug therapy, would be more effective than either compound …