[HTML][HTML] Shikonin attenuates acetaminophen-induced hepatotoxicity by upregulation of Nrf2 through Akt/GSK3β signaling
H Li, Y Chen, J Zhang, X Chen, Z Li, B Liu, L Zhang - Molecules, 2018 - mdpi.com
Acetaminophen (APAP) overdose-induced acute liver damage is mostly due to
overwhelmingly increased oxidative stress. Nuclear factor-erythroid 2-related factor2 (Nrf2)
plays an important role in alleviating APAP hepatic toxicity. Shikonin (SHK) enhances Nrf2 in
multiple lines of normal cells. Nevertheless, whether SHK protects against APAP-induced
liver toxicity remains undefined. This study found SHK defended APAP-induced liver toxicity,
as well as reversed the levels of serum alanine/aspartate aminotransferases (ALT/AST), liver …
overwhelmingly increased oxidative stress. Nuclear factor-erythroid 2-related factor2 (Nrf2)
plays an important role in alleviating APAP hepatic toxicity. Shikonin (SHK) enhances Nrf2 in
multiple lines of normal cells. Nevertheless, whether SHK protects against APAP-induced
liver toxicity remains undefined. This study found SHK defended APAP-induced liver toxicity,
as well as reversed the levels of serum alanine/aspartate aminotransferases (ALT/AST), liver …
Shikonin attenuates acetaminophen-induced hepatotoxicity by upregulation of Nrf2 through Akt/GSK3β signaling.
LHC Li HuaChao, CYM Chen YueMing… - 2019 - cabidigitallibrary.org
Acetaminophen (APAP) overdose-induced acute liver damage is mostly due to
overwhelmingly increased oxidative stress. Nuclear factor-erythroid 2-related factor2 (Nrf2)
plays an important role in alleviating APAP hepatic toxicity. Shikonin (SHK) enhances Nrf2 in
multiple lines of normal cells. Nevertheless, whether SHK protects against APAP-induced
liver toxicity remains undefined. This study found SHK defended APAP-induced liver toxicity,
as well as reversed the levels of serum alanine/aspartate aminotransferases (ALT/AST), liver …
overwhelmingly increased oxidative stress. Nuclear factor-erythroid 2-related factor2 (Nrf2)
plays an important role in alleviating APAP hepatic toxicity. Shikonin (SHK) enhances Nrf2 in
multiple lines of normal cells. Nevertheless, whether SHK protects against APAP-induced
liver toxicity remains undefined. This study found SHK defended APAP-induced liver toxicity,
as well as reversed the levels of serum alanine/aspartate aminotransferases (ALT/AST), liver …
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