Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males
M Baldassarri, N Picchiotti, F Fava, C Fallerini… - …, 2021 - thelancet.com
… We hypothesized that common polymorphisms may contribute to COVID-19 … the polyQ
tract of the Androgen Receptor (AR). AR contains in its N-terminus domain a polymorphic polyQ …
tract of the Androgen Receptor (AR). AR contains in its N-terminus domain a polymorphic polyQ …
Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in males
M Baldassarri, N Picchiotti, F Fava, C Fallerini… - medRxiv, 2020 - medrxiv.org
… polyQ tract of the Androgen Receptor (AR) may protect against the development of severe
COVID-19… AR contains in its N-terminus domain a polymorphic polyQ tract, ranging between 9 …
COVID-19… AR contains in its N-terminus domain a polymorphic polyQ tract, ranging between 9 …
[PDF][PDF] Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males
S Bologna - 2021 - academia.edu
… We hypothesized that common polymorphisms may contribute to COVID-19 … the polyQ
tract of the Androgen Receptor (AR). AR contains in its N-terminus domain a polymorphic polyQ …
tract of the Androgen Receptor (AR). AR contains in its N-terminus domain a polymorphic polyQ …
COVID-19 Severity and androgen receptor polymorphism
A Buonacquisto, AC Conflitti, F Pallotti, A Anzuini… - Biology, 2022 - mdpi.com
… high density of immune-related genes, some of which escape … different lengths of the
polyglutamine and polyglycine segments … in the androgen receptor and COVID-19 disease …
polyglutamine and polyglycine segments … in the androgen receptor and COVID-19 disease …
Do anti-androgens have potential as therapeutics for COVID-19?
F Mauvais-Jarvis - Endocrinology, 2021 - academic.oup.com
… the rapidly evolving field of androgen receptor (AR) action on … the AR polyQ tract and disease
severity, with shorter alleles (… and defective AR action, defined in this study as >23 PolyQ …
severity, with shorter alleles (… and defective AR action, defined in this study as >23 PolyQ …
The evolution and polymorphism of mono-amino acid repeats in androgen receptor and their regulatory role in health and disease
… neurodegenerative diseases, as shorter and longer alleles … polyglutamine regions of human
androgen receptor” and “The … to severe COVID-19 than patients with shorter CAG repeat (≤…
androgen receptor” and “The … to severe COVID-19 than patients with shorter CAG repeat (≤…
Host genetic basis of COVID-19: from phenotype to genes.
M Baldassarri - 2023 - usiena-air.unisi.it
… secondary to COVID-19 developed life-threatening thrombotic … The gene encoding androgen
receptor (AR), alternatively … of the AR PolyQ tract and its association with COVID-19 clinical …
receptor (AR), alternatively … of the AR PolyQ tract and its association with COVID-19 clinical …
A population-level analysis of the protective effects of androgen deprivation therapy against COVID-19 disease incidence and severity
… Testosterone and androgen receptor signaling may confer … Shorter CAG repeat length
increases AR sensitivity to … have identified genes strongly associated with testosterone levels. The …
increases AR sensitivity to … have identified genes strongly associated with testosterone levels. The …
Gender and genetic factors impacting COVID-19 severity
… Androgens bind to androgen receptors (ARs) which in turn act as an … [ 22 ] shows that the
presence of shorter polyQ tract among … [ 59 ] Genes DES and SPEG can be associated with …
presence of shorter polyQ tract among … [ 59 ] Genes DES and SPEG can be associated with …
SELP Asp603Asn and severe thrombosis in COVID-19 males: implication for anti P-selectin monoclonal antibodies treatment
… longer polyQ repeats (≥ 23) in the androgen receptor gene (… -Weinberg equilibrium; the
minor allele frequency in our cohort … to thromboembolism leading to life-threatening disease. We …
minor allele frequency in our cohort … to thromboembolism leading to life-threatening disease. We …