Significant association between IL23R and IL17F polymorphisms and clinical features of colorectal cancer

I Omrane, O Baroudi, K Bougatef, A Mezlini, A Abidi… - Immunology letters, 2014 - Elsevier
Th17 cells are involved in inflammatory and autoimmune diseases. These cells may be
involved in pathological processes mainly producing pro-inflammatory cytokines. Recently, it
was shown that the IL23/IL17 pathway plays an important role in the development of
inflammatory bowel disease. In general, genes encoding cytokines are genetically
polymorphic and polymorphisms in genes IL23R el IL17F were shown associated with
susceptibility to Crohn's disease and ulcerative colitis which in their turn are considered as …
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