Silica-Based Bismuth-Gadolinium Nanoparticles for MRI and CT Image-Guided Radiation Therapy
A Detappe, E Thomas, M Tibbitt… - International Journal of …, 2017 - redjournal.org
Results We found significant in vitro DNA double strand break damage when cells were
treated with SiBiGdNP (P< 0.001), a significant increase in apoptosis (P< 0.01), and
significant decrease in cell survival (P< 0.0001). In vivo magnetic resonance imaging (MRI)
and computed tomography (CT) contrast enhancement, and tumor suppression with
prolonged survival in a NSCLC model (P< 0.001) are observed. Histological studies show
minimal off-target toxicities due to nanoparticles or radiation. Conclusion By mimicking …
treated with SiBiGdNP (P< 0.001), a significant increase in apoptosis (P< 0.01), and
significant decrease in cell survival (P< 0.0001). In vivo magnetic resonance imaging (MRI)
and computed tomography (CT) contrast enhancement, and tumor suppression with
prolonged survival in a NSCLC model (P< 0.001) are observed. Histological studies show
minimal off-target toxicities due to nanoparticles or radiation. Conclusion By mimicking …
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