Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of α-synuclein, parkin, and DJ-1 in Caenorhabditis elegans
R Ved, S Saha, B Westlund, C Perier, L Burnam… - Journal of Biological …, 2005 - ASBMB
How genetic and environmental factors interact in Parkinson disease is poorly understood.
We have now compared the patterns of vulnerability and rescue of Caenorhabditis elegans
with genetic modifications of three different genetic factors implicated in Parkinson disease
(PD). We observed that expressing α-synuclein, deleting parkin (K08E3. 7), or knocking
down DJ-1 (B0432. 2) or parkin produces similar patterns of pharmacological vulnerability
and rescue. C. elegans lines with these genetic changes were more vulnerable than …
We have now compared the patterns of vulnerability and rescue of Caenorhabditis elegans
with genetic modifications of three different genetic factors implicated in Parkinson disease
(PD). We observed that expressing α-synuclein, deleting parkin (K08E3. 7), or knocking
down DJ-1 (B0432. 2) or parkin produces similar patterns of pharmacological vulnerability
and rescue. C. elegans lines with these genetic changes were more vulnerable than …
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