Parkinson's disease (PD) is the second-most prevalent neurodegenerative disorder,
characterized by the loss of dopaminergic neurons (mDA) in the midbrain. The underlying
mechanisms are only partly understood and there is no treatment to reverse PD progression.
Here, we investigated the disease mechanism using mDA neurons differentiated from
human induced pluripotent stem cells (hiPSCs) carrying the ILE368ASN mutation within the
PINK1 gene, which is strongly associated with PD. Single-cell RNA sequencing (RNAseq) …

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder,
characterized by the loss of dopaminergic neurons (mDA) in the midbrain. The
heterogenous pathology and complex underlying mechanisms are only partly understood
and there is no treatment able to reverse PD progression. Here, we targeted the disease
mechanisms by focusing on the ILE368ASN mutation within the PINK1 (PARK6) gene and
systematically characterized midbrain dopaminergic neurons obtained from human induced …