Sleep and inflammation: psychoneuroimmunology in the context of cardiovascular disease
SJ Motivala - Annals of Behavioral Medicine, 2011 - academic.oup.com
Annals of Behavioral Medicine, 2011•academic.oup.com
Background Poor sleep is prospectively linked to all-cause and cardiovascular mortality.
Inflammatory processes may be an important biological mechanism linking poor sleep to
cardiovascular disease. Such processes involve active participation of signaling molecules
called cytokines in development of atherosclerotic plaques. Purpose I review evidence from
experimental sleep deprivation and clinical observational studies suggesting a bidirectional
relationship between sleep and inflammatory cytokines. Results Findings from sleep …
Inflammatory processes may be an important biological mechanism linking poor sleep to
cardiovascular disease. Such processes involve active participation of signaling molecules
called cytokines in development of atherosclerotic plaques. Purpose I review evidence from
experimental sleep deprivation and clinical observational studies suggesting a bidirectional
relationship between sleep and inflammatory cytokines. Results Findings from sleep …
Background
Poor sleep is prospectively linked to all-cause and cardiovascular mortality. Inflammatory processes may be an important biological mechanism linking poor sleep to cardiovascular disease. Such processes involve active participation of signaling molecules called cytokines in development of atherosclerotic plaques.
Purpose
I review evidence from experimental sleep deprivation and clinical observational studies suggesting a bidirectional relationship between sleep and inflammatory cytokines.
Results
Findings from sleep deprivation studies indicate that sleep loss is associated with increases in these cytokines. Similarly, studies in clinical populations with sleep problems, such as primary insomnia patients and those diagnosed with major depression, also show elevations in these same cytokines.
Conclusions
Bidirectional communication between the brain and the immune system is carried out through a complex network of autonomic nerves, endocrine hormones, and cytokines. Disturbed sleep appears to perturb the functioning of this network and therefore contribute to elevations in inflammatory mediators linked to cardiovascular disease.
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