Smoke exposure of human macrophages reduces HDAC3 activity, resulting in enhanced inflammatory cytokine production
AR Winkler, KN Nocka, CMM Williams - Pulmonary pharmacology & …, 2012 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a debilitating condition resulting from
exposure to pollutants such as cigarette smoke. Pulmonary macrophages secrete a plethora
of inflammatory mediators that are increased in the lungs of COPD patients, but whether this
phenotype results directly from smoke exposure remains unknown. Using an in vitro model
for alveolar macrophages (AM) derived from human peripheral blood monocytes with
granulocyte-macrophage stimulating factor (GM-MØ), we analyzed the mechanistic …
exposure to pollutants such as cigarette smoke. Pulmonary macrophages secrete a plethora
of inflammatory mediators that are increased in the lungs of COPD patients, but whether this
phenotype results directly from smoke exposure remains unknown. Using an in vitro model
for alveolar macrophages (AM) derived from human peripheral blood monocytes with
granulocyte-macrophage stimulating factor (GM-MØ), we analyzed the mechanistic …
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